Today's thought concerns an email question that came across my desk today... it concerned solid tumor structure and the effectiveness of anti-cancer agents.
Recent studies on the tumor 'micro-environment' indicate that the abnormal structural parameters of solid tumors may restrict drug uptake by individual tumor cells buried within the tumor. This is a problem of drug delivery...should the tumor micro-environment be manipulated by agents that breakdown solid tumor structure to increase the efficiency of drug delivery?
This is a complex question and speaks directly to the biophysical parameters associated with tumors and their effects on the efficacy of chemotherapeutic agents....no doubt it plays a role in defining drug resistance properties that limit the general effectiveness of chemotherapy.
Friday, July 17, 2009
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