tag:blogger.com,1999:blog-60150807336929978562010-05-07T07:50:04.344-04:00Comments and discussion on new and important findings in cancer research. The latest results from the Cancer Biology Research Laboratory at Southern Connecticut State University in New Haven, Connecticut. Also---news and comment---from a cancer scientist's perspective---and invited feedback from experts and interested bloggers. New postings listed weekly!Dr. Sarah Crawfordhttp://www.blogger.com/profile/02400715898162643488crawfordsa321@gmail.comBlogger7125tag:blogger.com,1999:blog-6015080733692997856.post-2641421455171817462010-03-03T18:57:00.002-05:002010-03-03T19:03:26.326-05:00<p>Wednesday, March 3, 2010</p><p>Well, it's been a long time since I last wrote!</p><p> Busy winter--this past weekend my lab students presented their reserach at the New England Science Symposium at Harvard Medical School. Rafaela Penarreta gave a talk on her research on the use of a concentrated fern extract in pre-clinical studies of breast cancer solid tumors with different genetic signatures. Deanna Diamond, Laura Brustolon and Hua Wang presented posters. It was truly an amazing day!</p><p> </p><p>In April our lab will be presenting research at the Annual Meeting of the American Association for Cancer Research to be held in Washington, DC--it looks like a wonderful spring awaits.</p><p> </p><p>Who knows, I may start writing more often....</p><div class="blogger-post-footer"><img width='1' height='1' src='https://blogger.googleusercontent.com/tracker/6015080733692997856-264142145517181746?l=www.drsacrawford.com' alt='' /></div>Dr. Sarah Crawfordhttp://www.blogger.com/profile/02400715898162643488crawfordsa321@gmail.com1tag:blogger.com,1999:blog-6015080733692997856.post-41994852592131210782009-09-09T11:14:00.002-04:002009-09-09T11:19:49.478-04:00Welcome to all readers! A new semester begins- after a busy, but wonderful summer. I spent part of August in England. I gave a lecture at Cambridge University at the International Conference on Science and Society. It was a wonderful experience to give a presentation at this historic setting!<br /><br />This Fall, I will post cancer research news from my lab and from the cancer research scientific community. In mid-September, I will present our research at a meeting on stem cells at Cold Spring Harbor Laboratory. I will keep you posted on this important area of research.<div class="blogger-post-footer"><img width='1' height='1' src='https://blogger.googleusercontent.com/tracker/6015080733692997856-4199485259213121078?l=www.drsacrawford.com' alt='' /></div>Dr. Sarah Crawfordhttp://www.blogger.com/profile/02400715898162643488crawfordsa321@gmail.com0tag:blogger.com,1999:blog-6015080733692997856.post-68029977528542110902009-07-20T17:27:00.003-04:002009-07-20T17:33:01.651-04:00Monday, July 20, 2009<br /><br />Just a brief thought for today....About a century ago Dr Otto Warburg noticed that cancer cells have a high rate of glycolysis (glucose metabolism) compared to normal cells which process glucose completely to CO2 and H20 by a complex process called oxidative phosphorylation...this high glucose utilization by tumor cells is called 'The Warburg Effect' after its discoverer.<div class="blogger-post-footer"><img width='1' height='1' src='https://blogger.googleusercontent.com/tracker/6015080733692997856-6802997752854211090?l=www.drsacrawford.com' alt='' /></div>Dr. Sarah Crawfordhttp://www.blogger.com/profile/02400715898162643488crawfordsa321@gmail.com0tag:blogger.com,1999:blog-6015080733692997856.post-80668139622866389542009-07-17T11:50:00.001-04:002009-07-17T11:59:40.731-04:00Today's thought concerns an email question that came across my desk today... it concerned solid tumor structure and the effectiveness of anti-cancer agents.<br /><br /> Recent studies on the tumor 'micro-environment' indicate that the abnormal structural parameters of solid tumors may restrict drug uptake by individual tumor cells buried within the tumor. This is a problem of drug delivery...should the tumor micro-environment be manipulated by agents that breakdown solid tumor structure to increase the efficiency of drug delivery? <br /><br />This is a complex question and speaks directly to the biophysical parameters associated with tumors and their effects on the efficacy of chemotherapeutic agents....no doubt it plays a role in defining drug resistance properties that limit the general effectiveness of chemotherapy.<div class="blogger-post-footer"><img width='1' height='1' src='https://blogger.googleusercontent.com/tracker/6015080733692997856-8066813962286638954?l=www.drsacrawford.com' alt='' /></div>Dr. Sarah Crawfordhttp://www.blogger.com/profile/02400715898162643488crawfordsa321@gmail.com0tag:blogger.com,1999:blog-6015080733692997856.post-89816590970577211072009-07-16T11:24:00.000-04:002009-07-16T11:30:00.974-04:00Hi readers<div><br /></div><div>Right now we are studying the anti-cancer properties of ferns- we are studying ferns endogenous to the Northeast USA and have recently engaged the assistance of the NY Botanical garden who will provide samples of ferns from this region so that we can assess the individual species for potential anti-cancer activity in human solid tumor cell lines representative of many types of cancer.</div><div><br /></div><div>More on this tomorrow....</div><div class="blogger-post-footer"><img width='1' height='1' src='https://blogger.googleusercontent.com/tracker/6015080733692997856-8981659097057721107?l=www.drsacrawford.com' alt='' /></div>Dr. Sarah Crawfordhttp://www.blogger.com/profile/02400715898162643488crawfordsa321@gmail.com0tag:blogger.com,1999:blog-6015080733692997856.post-78121351099351997112009-07-15T09:38:00.000-04:002009-07-15T09:47:24.715-04:00Wednesday, July 15, 2009<div><br /></div><div>hi to  new and future bloggers!  Each day I will touch upon some aspect of current cancer research studies in my lab-- and other labs--and hope to present info of interest to many who follow progress in cancer research...</div><div><br /></div><div>Beginning tomorrow- I will post a new item each day.</div><div><br /></div><div>Best wishes!</div><div class="blogger-post-footer"><img width='1' height='1' src='https://blogger.googleusercontent.com/tracker/6015080733692997856-7812135109935199711?l=www.drsacrawford.com' alt='' /></div>Dr. Sarah Crawfordhttp://www.blogger.com/profile/02400715898162643488crawfordsa321@gmail.com0tag:blogger.com,1999:blog-6015080733692997856.post-51881727456268690662009-07-14T14:22:00.000-04:002009-07-14T14:28:28.827-04:00Welcome to my newly created blog site!<div><br /></div><div>I am hoping to share and discuss many new and exciting results from the world of cancer research that may increase our understanding of the nature of cancer, its treatment and prevention.</div><div><br /></div><div>I will use this forum to present our ongoing research studies in my Cancer Biology Research Laboratory, and also to present important findings from around the world that are contributing to the study of this disease.</div><div><br /></div><div>I hope this ongoing dialog will be rewarding for all participants!</div><div class="blogger-post-footer"><img width='1' height='1' src='https://blogger.googleusercontent.com/tracker/6015080733692997856-5188172745626869066?l=www.drsacrawford.com' alt='' /></div>Dr. Sarah Crawfordhttp://www.blogger.com/profile/02400715898162643488crawfordsa321@gmail.com0